This article sheds light on the relationship between Israeli high-tech innovation and military/security production in the framework of settler-colonialism and the prolonged occupation of the Palestinian territories. It analyzes the global rise of Israel in military and security innovation as a result of decades-long colonial ventures and regional wars, which have been a key variable for dynamic and extensive innovation and productivity. Moreover, the article argues that Israeli military and security would not have been attainable without the extraordinary official assistance and private investment from the United States, especially since the aftermath of the 1967 war. Besides the structural dependency on the US, this article highlights other characteristics that define Israel’s military and security production, such as the vicious nature of these innovations, complicity in global atrocities, and profitability of innovation to Israel’s war economy. Finally, the article presents Gaza’s Great March of Return (gmr) as a case study to present evidence on the ways in which Israeli military forces and security companies are jointly involved in experimentation, using new weapons and unmanned devices on the Palestinian civilians.